2. Signaling Pathways
  3. Vitamin D Related/Nuclear Receptor
  4. Thyroid Hormone Receptor

Thyroid Hormone Receptor

THR

Thyroid Hormone Receptor

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Thyroid hormone receptor is a member of the nuclear receptor superfamily that shuttles between the cytosol and nucleus. Thyroid hormone receptors are ligand-dependent transcription factors that mediate the biological activities of thyroid hormone (T3). Thyroid hormone receptors are encoded by two genes, one for TRα and another for TRβ, which encode the major isoforms of TR, including TRα1, TRα2, TRβ1, and TRβ2. The thyroid hormone receptors mediate the pleiotropic activities of the thyroid hormone (T3) in growth, development, and differentiation and in maintaining metabolic homeostasis.

Thyroid hormone receptors are zinc finger transcription factors in the erbA superfamily that bind DNA at specific response element sequences (thyroid hormone response elements, TREs) and activate gene expression in response to thyroid hormone (T3). Thyroid hormone receptors have been shown to bind DNA as monomers, homodimers, or heterodimers with another erbA superfamily member, the retinoid X receptor (RXR).

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-160266
    THR-β agonist 7
    		Agonist
    THR-β agonist-1 (Example 2) is a THR-β agonist, with EC50 values of 52 nM and 1017 nM for THR-β and THR-α, respectively.
    THR-β agonist 7
  • HY-160416
    THR-β modulator-2
    		Modulator
    THR-β modulator-2 (compound 40) is a thyroid hormone receptor β (THR-β) modulator.
    THR-β modulator-2
  • HY-A0070R
    Liothyronine (sodium) (Standard)
    		Activator
    Liothyronine (sodium) (Standard) is the analytical standard of Liothyronine (sodium). This product is intended for research and analytical applications. Liothyronine sodium is an active form of thyroid hormone. Liothyronine sodium is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively.
    Liothyronine (sodium) (Standard)
  • HY-W010669R
    L-Thyroxine sodium xhydrate (Standard)
    L-Thyroxine sodium xhydrate (Standard) is the analytical standard of L-Thyroxine sodium xhydrate. This product is intended for research and analytical applications. L-Thyroxine sodium xhydrate (Levothyroxine; T4) is a synthetic hormone in the treatment of hypothyroidism. DIO enzymes convert biologically active hormone (Triiodothyronine,T3) from L-Thyroxine (T4).
    L-Thyroxine sodium xhydrate (Standard)
  • HY-B0208R
    Methimazole (Standard)
    		Inhibitor
    Methimazole (Standard) (Thiamazole (Standard)) is the analytical standard of Methimazole (HY-B0208) . This product is intended for research and analytical applications. Methimazole (Thiamazole) is an anti-thyroid agent, which blocks thyroid hormone production from the thyroid gland. Metamizol can cause hepatotoxicity.
    Methimazole (Standard)
  • HY-U00220
    KAT681
    KAT681 is a liver-selective thyromimetic.
    KAT681
Cat. No. Product Name / Synonyms Application Reactivity